Chemical Mimicry of PCH1B

We have a new paper under review! Our laboratory developed a novel cell line to model Pontocerebellar Hypoplasia type 1B (PCH1B) from stem cells obtained from a patient’s blood (and heterozygous normal parents). In this paper, we show that chemical induction of disease by ERD03 (previously published in ACS Chemical Biology) recapitulates many of the hubs and nodes found in the proteomic data from the patient with the disease.

Check out the preprint at iScience