Our new publication "In Silico Targeting of the Long Noncoding RNA MALAT1" is online at https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00060
RNA is a difficult drug target, with only a few FDA-approved therapeutics. In this study, we used a virtual screen against MALAT1 and validated a compound that is specific to this structured RNA. This work demonstrates that in silico methods designed for protein targets can be used to target a structured RNA, expanding the available strategies for drug design for these targets.
